MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the mitochondrial genome. Discovered in 2015, it is one of the first known mitochondrial-encoded signaling peptides and has emerged as a critical regulator of metabolic homeostasis.

Molecular Profile:

• Molecular Weight: 2,174.6 g/mol
• Length: 16 amino acids
• Sequence: MRWQEMGYIFYPRKLR
• Origin: Mitochondrial 12S rRNA gene

Research Applications:

• AMPK activation and cellular energy sensing
• Glucose metabolism and insulin sensitivity studies
• Exercise mimetic and endurance performance models
• Mitochondrial-nuclear communication (retrograde signaling)
• Aging-associated metabolic decline countermeasures
• Folate-methionine cycle and epigenetic regulation
• Skeletal muscle metabolism and adaptation studies

Quality Standards:

• Purity: ≥99% verified by HPLC
• Third-party tested with COA included

FOR RESEARCH USE ONLY. Not for human consumption.